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The positive feedback loop results in significantly increased endothelial cell proliferation and angiogenesis.Given the complex interactions of perlecan as a matrix molecule and its potential to serve as a repository for angiogenic growth factors, it is not surprising that much remains unresolved.Perlecan is unique in its structure, is a single family member, yet is indispensable for invertebrate and vertebrate life.To counterbalance this, perlecan expression may augment the growth and survival of a range of tumor types, in part by promoting some of the same vascular effects that are required in cardiovascular development.It would be revealing to uncover the molecular basis by which some tumors are promoted by the presence of perlecan, while http://inhibit09.online/archives/53 others are inhibited.With such detailed understanding it may become possible to intervene in the unwanted side of perlecans properties.Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.Perlecan maintains the integrity of cartilage and some basement membranes.Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor.Vascular endothelial growth http://inhibit09.online/archives/59 factor overexpression stimulates angiogenesis and induces cyst formation and macrophage infiltration in human ovarian cancer xenografts.Heterozygous embryonic lethality induced by target inactivion of the VEGF gene.SU is a potent and selective inhibitor of the vascular endothelial growth factor receptor that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.Sequence, recombinant analysis and tissue expression.Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate.A short peptide domain of platelet factor blocks angiogenic key events induced by FGF.Gene therapy for pancreatic cancer using an adenovirus vector encoding soluble flt vascular endothelial growth factor receptor.Antiangiogenesis treatment of gliomas: transfer of antisensevascular endothelial growth factor inhibits tumor growth in vivo.Generation of receptorselective VEGF variants by sitedirected mutagenesis.Quantitative analysis of basic fibroblast growth factor and vascular endothelial growth factor in human colorectal cancer.Introduction of basic fibroblast growth factor gene into mouse renal carcinoma cell line enhances its metastatic potential.A chimeric molecule with multi domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules and epidermal growth factor.The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoproteinreceptor and neural cell adhesion molecule.Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors.High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.Enhanced expression of basementmembranetype heparan sulfate proteoglycan in tumor fibromyxoid stroma of intrahepatic cholangiocarcinoma.Antivascular endothelial growth factor receptor antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type production.Role of sinusoidal heparan sulfate proteoglycan in liver metastasis formation.Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma.Annu Rev Med: Twoprocesses are re sponsib le for the formation of newblood vesse ls, bo th of wh ich resu lt in the forma tion ofsimp le, endo thelium lined, capil la ry like tube s.The first is va scu logenesi s, which is the pr imary in situ differentiation of endo thelial cells from mesode rmalpre cursors, and the ir subsequentorgan ization in to a pr imary capil laryplexu s.

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