The present chapter summarizes all the scientic researches so far being done on the plant to make an attempt to unveil its secondary metabolites so that their therapeutic properties could be assessed.Humans utilized plants and plant products to fulll all the most important necessities for their nourishment, and their existence is extremely reliant on primary producers, mostly plants.Near about plant species have been widely utilized by humans as food.Besides fullling primary needs, the plant species have been utilized as medicines for various human illnesses. Such plants are called traditional medicinal plants and have played the most important roles in our ancient system of medicine.Those plants have been provided hypothesis and become primary source of modern drug discovery by the pharmaceutical industry.This family is represented by species belonging to genera. Many species belonging to this family are greatly aromatic and mainly produce oil that evaporates in low temperature due to the existence of peripheral glandular structures. This genus normally consists of approximately species.Books and journals available in library were also consulted while preparing this manuscript.More than articles were studied of which important references are included in this chapter.This plant is also used as a purgative agent and widely used as a bitter tonic and appetizer, and is also helpful in expulsion of fetus. It is also used as a herbal tea due to its stimulating and antispasmodic properties. It is often made into a syrup or candy, though it can be used as a tea. Due to bitter nature, this plant species is also helpful in digestive functioning of the stomach. Traditionally, this herb has been considered helpful for the treatment of persistent fever and cholera. The tiny amount of marrubiin, a labdane diterpene, has the potential to normalize heartbeats.The hot waterextract is used as sweatinducer, whereas the cold infusion of bitter taste is used as tonic for digestion.It is also useful in treating sore wounds.The presence of highly volatile constituents makes it the best stimulant and antihelmintic, as well as useful in amenorrhea, chronic rheumatism, dyspepsia, and hepatitis. The extract assists to destroy cankerworms when sprayed on fruiting trees.It is also used to ease heartburn, in digestion, and to raze worms in human intestine.A candy formulation that contains fresh leaves, crushed seeds of cardamom, one teaspoon anise seed, and mL water is used as a standard care for cough in children aged between and years. In a separate research, the lowpressurebased chromatographic method was developed for the marrubiin isolation. A novel compound, oxomarrubiin, was identied from methanol extract. Vulgarcoside A, a diglycoside derivative of the diterpene peregrinol, was isolated from this plant. Sahpaz and coworkers have reported few phenylethanoid glycosides such as marruboside and acetyl marruboside. They include monoterpenes, sesquiterpenes, and esters.In folklore, inammation and neurosedative disorders are treated.The hydroalcoholic extract were studied separately, which exhibited signicant antiinammatory activities.It was observed that extract administered orally with dosages of, and mgkghsignicantly reduces levels of tumor necrosis factor and peripheral neutrophil count.In case of indomethacininduced ulcers, methanolic extract exhibited potential activity at a dose of mgkg and cimetidine showed similar efcacy at a dose of mgkg.