Additional exploration revealed that CBD affects learning and memory of aversive events, processes related to PTSD pathophysiology. The proinammatory cytokines IFN and TNF were also decreased in plasma by treatment with CBD.Treatment of old female NOD mice with CBD for weeks either in the initial symptoms of Targetmol’s Ospemifene diabetes or in inactive diabetes stage enhances the appearance of the disease.There is reduction in the level of the cytokine IL and increase in the level of IL. Pathophysiological alterations in the vasculature are the major complication of diabetes mellitus.Retinopathy and nephropathy are microvascular complications, while common macrovascular complication of diabetes is atherosclerosis.Studies with CBD are carried out on rats induced by streptozotocin showing its protective effects.Treatment with CBD barred death of retinal cells and increase the vascular permeability.Its treatment also results in the reduction of oxidative stress and decreased the levels of TNF, vascular endothelial growth factor and intercellular adhesion molecule. It also shows effectiveness against other complications in diabetes and atherosclerosis. The symptoms of RA and AS are fatigue and pain, cognitive dysfunctions like concentration and memory problem.AS is characterized by back pain and stiffness and affects spinal and sacroiliac joints; this disease involves numerous pain mechanisms, and there is a clinical challenge for the treatment of these diseases.Nociceptive and nonnociceptive components may be involved in treatment of pain related to RA and AS.It is established on the interaction between central sensitization and peripheral inammation. The immediate pain is initiated by the swelling of the synovial tissue andor consecutive oedema of the subchondral bone which causes pain leading to a sensitization of the peripheral nociceptors. Thus, peripheral nociceptors and central neuropathic pain mechanism at different stages cause chronic.CB is found mainly in the brain and nervous system, whereas CB is expressed predominantly by immune cells.CBD induced the endoplasmic reticulum stress which inhibits AKT and mTOR signalling as shown by decreased levels of phosphorylated mTOR and EBP and cyclin D.CBD was shown to be more effective inhibitors of human breast cancer cells among three groups of cannabinoid compounds tested.Synthesized compounds with afnity for CBD and CBD receptors.CBD regulates the genes which are responsible for proliferation of cells and invasion.With this property, it is known to reduce tumour aggressiveness.Cannabidiol repressed the proliferation, migration and invasion of HUVE cells by inducing cytostasis of the endothelial cells without apoptosis. CBD also have analgesic effect in hyperalgesic and inammatory states. The dissociative effect of THC on the pain was not indicated by peripheral mechanisms alone.It has been shown that the activation of amygdala leads to the interindividual reaction to cannabinoid analgesia, and there is a dissociative effect of tetrahydrocannabidiol in the brain, which results in pain relief in humans. THC and CBD were known to have best painrelieving properties.THC also has detrimental memory effects that are lessened by CBD.Researchers attributed this to the CBD that is found in cannabis. The world is gradually accommodating CBD as a potential treatment for a number of medical conditions.Cannabis used in the research area for treating HIV symptoms has also advanced.