Inammation as well as oxidative stress can result in the pathogenesis of chronic diseases and metabolic disorders.The antiinammatory potentials and the activity related to antioxidation stress due to phenolics can essentially affect similar biomarkers. The avonoids such as procyanidin and apigenin have also been reported to be capable of inhibiting inammasome activation and interlukin secretion in the lipopolysaccharideinstigated human macrophages. The stilbene phenolic compound named resveratrol present in red grapes also caused inhibition of NLRP activationinstigated autophagy for the preservation of mitochondrial function in both in vitro as well as in vivo studies.The phenolic compounds obtained from dietary sources like plant foods, herbs and spices can trigger PPAR to reveal protagonist consequences on the transcription factors of inammation, resulting in the repression of inammation and inhibitory consequence on the metabolic diseases.Resveratrol has an agonistic action on SIRT for the protection of cells from inammatory damages. Since, the dietary polyphenols have less absorption rate, less amounts of such compounds having physiological relevance can still alter the expression of several inammatory biomarkers through different signaling pathways.In order to produce effects, therapeutical drugs target these biomarkers, therefore, the capability of dietary phenolics on the same proinammatory cytokines as well as other signaling molecules can have signicant positive effect in preventing chronic noncommunicable diseases due to oxidative stress.Accumulating evidences are indicative of enhanced antiinammatory potentials of herbs that have undergone through the process of fermentation.A ratelimiting enzyme, namely cycloxygenase, exhibits regulatory effect in the production of various inammatory mediators that are active in biological systems, like prostaglandinE, which is also activated in various carcinomas, thereby, indicating its important part in inammation as well as tumor genesis. Thus, it was concluded from these ndings that fermentation increased the potential of the antiinammatory effect of OY by obstructing NF and MAPK pathway in the macrophage cells. By reviewing the potent role of plant extracts, essential oils and compounds derived from natural products along with their mechanisms on oxidative stress and inammationrelated biomarkers, it is hoped that future efforts in this respect can focus on increasing the bioaccessibility, bioavailability from processing and formulation of plantbased functional foods, and ultimately this will develop functional foods or nutraceuticals that will decrease health risk of chronic diseases because of their modulatory effects.Although production of drugs from the plantbased antiinammatory compounds may prove a difcult task, but plant extracts, essential oils and pure compounds of natural products may still open new areas for therapeutic interventions.mouse macrophage cells.Different treatment strategies have been utilized to manage with this situation including use of different nonsteroidal antiinammatory drugs and other diseasemodifying agents.In recent years, different newer natural agents have been screened for their antiinammatory activity, and one such agent is cannabidiol, which has signicant activity against inammation.Besides, antiinammatory activity, this plant species also possess different activities like neuroprotective, antiepileptic, hypoxiaischemia, anxiolytic, antipsychotic, analgesic, antiasthmatic, and antitumor properties.In this communication, antiinammatory effects of CBD are described along with its mechanism of action and pharmacokinetic studies.Body shows its defensive response to get rid of, or suppressing the expansion of, infectious agent and subsequent eradication of localized dead tissues.