Different national and internationally recognized pharmacopoeias have focused on the safety evaluation of these natural drugs with their potential therapeutic effects.Recently, the trends on medicinal plants research have a specic paradigm shifting with major biotechnological approaches and post marketing innovations on multiple modes of action.Pharmacological industries have faced critical challenges for practical application of medicinal drugs in terms of their safety issues and expenses. The modern dynamic technologies have moved on opposite directions of the traditional herbal cure methodologies with much faster reverse pharmacological approaches. Screening, standardization, and modied clinical observation have biodynamic and exploratory potentiality for optimizing the level of acceptability and bioaccessibility.Moreover, the reverse pharmacology also signied the selective bioprospection of active constituents of plant parts and exclusion of poisonous ingredients with safety issues. Recently, the developing countries have developed drug act for the inclusion of active phytoingredients of different medicinal plants with pluralistic and opportunistic healthcare complexes. The process of reverse pharmacology follows targeted proteinaceous action and emerging dimension in sequence technology with target mining actions.Distant homologies and ligand shing can be identied during drug moderation, and mechanistic basis of indexed biological processes is involved. It is an interbridging community between the molecular genomics and pathophysiology for the development of superior drug candidate.Extracts of the dried roots caused targeted inhibition of neuroendocrinal effects. Currently, the effect of alkaloids on H receptor, inammation inhibitory, and pharmacovigilance activity has been the focus of different researchers throughout the world.There are chances of alterations in the samples which could lead to a threat to consumers health.In recent years, there is increase in the consumption of the herbal medicines due to its more safety values than that of allopathic medicines.So, it leads to greater chances of adulteration of herbal medicines. Very less research has been done in case of safety of herbal medicines.Processing stage is the step where the herbal medicines can get contaminated even by slightly miss caring.Moreover, most of the natural products do not get proper evaluation at the laboratory level by the regulatory authorities, as result of which these products fail to prove their efcacy at the molecular level. There are variabilities that are found in the herbal medicinal products at the inherited level.Also, variability is found at the batchtobatch level, and absence of proper standard reference material also adds some more difculties in the quality control assessment of herbal products. It is believed that risks associated with herbal medicines are very low, but this is not the case, there are risks associated with the contamination in herbal products.In spite of their proved therapeutic potential, global utilization remains limited due to the fact that their mode of action and standardization were not tested during application.Therefore, based on overall reports, this chapter concludes that the herbal medicines can be utilized as an alternative medicine after complete proling and testing the exact mode of action.Vaccine and their active constituents in diseases prevention and treatment.A reservoir plant for therapeutic applications: an overview.Phytomedicine WHO traditional medicine strategy. In spite of unprecedented advances in modern system of medicine, people in the diseaseprone area have been taking traditional medicinal plants or plantderived products to increase the life span of patients.