NFB is required for transcriptional ac tivity of the IL promoter.AP and CEBPNFIL a lso regulate transcr ipt ion in a celldependent manner under cer ta in pathophysiologic condit ions.Maximalactivat ion occurs with the interac tion of the three transcription fac tors.The untranslated region of the gene is also implicated in the regulation of IL.The authors suggested that calcineurin mediates the degradation of IB, perhaps through the activation of IB kinases, resulting in increased nuclear translocation of NFB and transcription at the IL promoter. Most chemok ine receptors were in itially described in associat ionwith the study of leukocy tes, but it has become evident that their expression is more ubiquitous, having been shown for endothelial cells, epithelium, neurons, astrocytes, and microglia in the brain, as well as for a variety of tumor cells. Two homo logouschemokine recep tors, CXCR, bind to IL with high af nity. They share sequence identity and are currently considered to be the only biologically signif icant IL receptors. Theirgenes, IL R A and IL RB, each of which is encoded by a single exon, are located kb apart on chromosome q, and they are associated with an inactive CXCR pseudogene, IL RP. At the cell surface, CXCR shows binding only for IL and GCP, without appreciable afnity for other CXC chemok ines. In contrast, CXCR binds to IL as well as other CXC chemok ineswith similarhigh afnity, includ ing ENA; GRO, and; neut rophil activat ing pro tein; a nd GC P. Duffy antigen receptor for cy tok ines binds to both CXC and CC cy tok ines with relative promiscuity.However, DARC lacks the protein motif in its second intracellular loop that is required for coupling to G proteins, and it has not yet been linked to any intracellular Eplerenone signaling pathways.It is possible that th is receptor ac ts as a molecu lar sink for bind ing and degradat ion of chemok ines through receptor internalizat ion or that it participates in chemok ine transpor t.Of par ticu lar relevance to tumorigenesis, IL is a potent mediator of ang iogenesis. Bimatoprost angiogenesis is the process by which new blood vessels a re formedfrom preex ist ing ones and fol lows a complex sequence of events that occurs in response to proangiogenic and antiangiogenic factors. This process is tightly regulated and is activated on ly in patholog ic states such as wound healing and neoplasia, and in limited physiologic set tings such as menstrual cycle events.The beg inning phase of angiogenesis is associated with increased vascular permeability of parent vessels that leads to extravasation of plasma and deposition of proangiogenic matrix proteins.In response to the mitogenic effects of proangiogenic cytokines, endothelial cells proliferate and then migrate along a chemotactic gradient into the extracellu lar matr ix.Once establ ished, endothel ialcel ls form tubeswith a central lumen, elaborate a new basement membrane, and eventually recruit pericytes and smooth muscle cells to surround the mature vessels.The proangiogenic properties of IL were rst demonstrated in the early s, when recombinant human IL was shown to have chemotactic properties on human umbilical vein endothel ial cel ls.