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. Pesce M, Orlandi A, Iachininoto MG, et al: Myoen dothelial differentiation of human umbilical cord Downloaded from at PENNSYLVANIA STATE UNIV on March, Vascular and Endovascular Surgery Volume, Number, Eplerenone Acronyms ECs, Endothelial cells ECM, Extracellular matrix MMP, Matrix metalloproteinases HSC, Hematopoietic stem cell EPC, Endothelial progenitor cell MAPC, Multipotent adult progenitor cell VEGF, Vascular endothelial growth factor VEGFR, Vascular endothelial growth factorreceptor PLGF, Placenta like growth factor SDF, Stromalcellderived factor CABG, Coronary artery bypass grafting PECAM, Platelet endothelial cell adhesion molecule vWF, von Willebrand Factor CFU, colony forming unit PDGF, Plateletderived growth factor TGFb, Transforming growth factorbeta BMMC, Bonemarrowderived mononuclear cells HMVEC, Human microvascular endothelial cells KDR, Kinase domain receptor NOS, Nitric oxide synthesis CAD, Coronary artery disease Downloaded from at PENNSYLVANIA STATE UNIV on March, These discrete phases each have unique properties; a diffusible tumor angiogenesis factor seems to be responsible for initiating the vascular phase; and when the avascular phase is prolonged, solid tumors in a variety of experimental models fail to grow beyond a few millimetres.This perspective of the manner by which solid tumors grow has become a guide for further experiments to elucidate the nature of tumor angiogenesis factor, to determine whether tumor neovascularization can be inhibited, and to find out whether the neovascularization that sometimes accompanies wound healing, inflammation, or delayed hypersensitivity operates through a different mechanism than tumor angiogenesis.T HE MANNER by wh ich leukem ic cells survive in the host is easier to compreh endth an the survival of cells in a solidtumor.Leukem ic cells live most of the ir life inside thebloodst ream and a re immersed in a flowing nutr ient th at also carr ies was teproducts from the neop lastic cells.Sp inner cultu re wou ld be an app rox im a te in vit ro ex amp le.Howeve r, cells in a solidtum or live, for the most part, ou ts ide thebloodst ream in acrowded popu lation for wh ich conventional tissue cultu re is not a good ana logue.It is becom ing app are ntth at la rge, dense popu Mebeverine hydrochloride lations of cellswi th in solidtumors can exist only becau se the tum or itselfst imu la tes the fo rmation of new capil lar ies.Although it was once generally cons ide red th at the vascu lar reaction in the ne ighbo rhood of solid neop lasms was some seconda ry or inflamma to ry by p rodu ct oftum or grow th, recent studies suggest amo re cruc ial ro le for the blood vessels elicited bytumor.Wepropo se th attum or neovascu larization is the resu lt of a specifichumor al st imu lus secre ted by thetum or to elicit new capil lar ies from the hos t, and th at these vessels, in tu rn,be come an import a nt control mechanism in thegrow th of thetumor.T he po int at wh ich a solidtum or is firstpenetrated by new capil lar ies occu rs early intum orgrow th and divides the life of a solidtum or in to two phases, be fo re vascu lari zation and after vascu larization.

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