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19]][“H Inhibitor”

The decrease in CD in chickens and hamsters is accompanied by decreased blood flow. In chickens there is also a decrease in oxidative capacity, which is highest at hatching, both in slow muscles together with their decreased activity and increased activity of glycolytic enzymes. Similar parallel adjustment of the capillary sup ply to the differentiation of oxidative capacity was seen in rabbits and kittens. Both in the heart and in skeletal muscles, capillar ies develop from angioblasts, and larger vessels are formed from capillary networks.Stretch exerted by the Tetracycline hydrochloride growth of surrounding tissue is an important factor in skeletal muscle.Capillary growth in the left ventricle is considerably Silodosin faster than in the right ventricle; the force of contraction and cardiac work against high resistance may thus represent a potent stimulus for capillary growth in the heart.Chronic hyperoxia stimulates and hypoxia retards organ growth in chick embryos, and human fetuses grow less in mothers living at high altitude. How ever, in adult organisms the effect of hyperoxia and hyp oxia appear to have similar consequences, leading to in creased capillarization in the right but not in the left ventricle, either with hyperoxia or right ventricular hypertrophy have described some increase in capillarization in the right ventricle in rats and guinea pigs but not in dogs did not find any change in CD either in the right or in the left ventricle in rats exposed to high altitude, so it is not likely that decreased oxygen tension is the stimu lus for capillary growth via metabolic factors.Whether blood flow is also increased in hyperoxiain duced hypertrophy in conjunction with increased work load is a matter for further investigation.However, coro nary blood flow was increased in guinea pigs exposed to low temperatures that induced cardiac hypertrophy, but this affected neither CD nor CF. Exposure to cold could also explain the in creased mitochondrial size and number in the red part of vastus lateralis and increased succinate dehy drogenase activity in red parts of diaphragm and rectus femoris in guinea pigs bred at high altitude. Banchero also proposed that tissue hypoxia can result from cold expo sure or exercise regimes that increase the muscle de mand for oxygen.It is worthwhile to remember that exposure to cold or high altitude can stimulate capillary growth by fac tors connected with increased blood flow.It could be expected, therefore, that exercise, particu larly if performed vigorously for a long time, would re sult in an increase in CD.Surprisingly, this happens only to a limited extent and mostly in young animals.In contrast, decreased CD with no change in CF was found in guinea pigs trained on a treadmill. To what extent capillary growth is related to the intensity of training is also a matter of controversy.Moderate training of young animals led to an increased CD and a decreased ICD, but although CF was increased in young rats that swam for hdaily for wk, swimming twice a week was without effect. If the workload was increased by the animals carrying weights, an increased CF was found even in rats that swam only twice weekly also showed a direct relationship between increased capillarization and the total distance andor speed of running.

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