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Inhibitor Enzim

On the other hand, it significantly increases red blood cell velocity in cardiac microcirculation, the results of which could be increases in both shear stress and capillary wall ten sion.All these findings indicate that vasodilators may stimulate capillary proliferation by mechanical events resulting from increased blood flow.If so, a drug that increases flow in skeletal muscle but not in the heart should increase capillarization in the former but not in the latter.Indeed, prazosin, an alblocker, almost tre bledflow in skeletal muscles but did not change it appre ciably in the heart, and capillarization was significantly increased in the former but not in the latter. Increases in CF as well as in CD after prazosin treatment occurred in both fast and slow muscles but by different mechanisms: in the fast tibialis anterior it could have been due to in creased red blood cell velocity and increased shear stress, whereas in soleus it resulted possibly from in creased capillary diameters and wall tension. Adaptation to the external environment and ex ercise training do not seem to stimulate capillary growth in the heart.In skeletal muscle, exposure to low temperatures alone, or in combination with hypoxia, re sults in increased CD, but this is more likely due to a decrease in fiber size.Endurance training, on the other hand, results in capillary growth occurring mainly in the vicinity of fibers recruited during this type of train ing, which can be explained or linked with an increase in blood flow.Increased blood flow is also the main factor involved in capillary growth in electrically stimulated muscles and, of course, as a result of longterm adminis tration of vasodilating drugs in both skeletal muscles and the heart.In contrast, growth of capillaries in the heart resulting from longterm Calcium gluconate bradycardia does not seem to be stimulated by increased coronary flow but rather by changes in capillary wall tension.When CD or CF is taken as an indicator of capillary growth, it is important to remember that in any one species CD is inversely related to the heart size or fiber area, and any changes therefore have to be considered bearing in mind that larger hearts would have a lower CD, whereas CF seems to be less dependent on fiber size.Whatever parameters have been used, most papers report a decrease in CD or CF in most types of hypertrophy, but it is often difficult to interpret whether the lower values are simply due to larger fibers or whether there is a real loss of capil laries.Right ventricular hypertrophy occurs during long term exposure to low PO, and growth of capillaries under these circumstances, or its absence, was discussed in section VAZ.Left ventricular hypertrophy has been demonstrated in hyperthyroidism, and during pressure overload or volume overload. The remaining viable tissue expanded by, with a loss of of capillary surface when infarcts affected of the left ventricle; cellular hypertrophy in infarcts Telmisartan affecting of the left ventricle was more extensive and was accom panied by a greater loss of capillary surface area.Decreases in the total capillary length per ventricle were even greater, in smaller and in larger infarcts, and the total capillary lumen was also smaller.

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